Nanohedra: Using symmetry to design self assembling protein cages, layers, crystals, and filaments

By Jennifer E. Padilla, Chris Colovos, Todd O. Yeates. 2001

429 citations recorded by the source corpus.

Subfields: Biomaterials, Ecology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Ecology

In Molecular Biology

Citations in the corpus

Metal-directed, chemically-tunable assembly of one-, two- and three-dimensional crystalline protein arrays (2012, positive): “Combining the symmetry-and directional bonding-based self-assembly strategies of others 17, 19, 20 , we posited that, if two or more selective Zn coordination sites on the MBPC1 surface could be stabilized in appropriate orientations relative to each other, it should be possible to dictate the…”
Computational design of a protein crystal (2012, background): “Nanometer scale nanohedra and filaments have been prespecified using heterodimers of known self-associating protein domains (20).”
De novo protein design, a retrospective (2020, background): “Yates and coworkers (Padilla et al., 2001; Yeates, 2017) described general principles for the design of symmetrical virus-like assemblies that form large molecular cages by rigid fusions of two oligomeric proteins – for example, one that forms a C2 dimer with one that forms a C3 trimer – so that the”
Engineered and designed peptide-based fibrous biomaterials (2004, background): “Yeates and colleagues offer a third approach to the design of protein fibres [ 71 ].”
Generation of ordered protein assemblies using rigid three-body fusion (2020, positive): “The genetic fusion route was originally demonstrated with the creation of a tetrahedral protein nanocage and fiber (5) and has since been used to generate two-dimensional (2D) layers (6), a porous cube (7), additional tetrahedra (8, 9), octahedra (10), and icosahedra (11, 12).”
Nanotechnology: convergence with modern biology and medicine. (2003, background): “the design of molecules as building blocks [44]).”