Computational design of a protein crystal

By C. Lanci, Christopher M. MacDermaid, Seung-gu Keng, Rudresh Acharya, Benjamin North, Xi Yang, J. Qiu, William F. DeGrado, J. Saven, Seung-gu Kang and 1 more. 2012

173 citations recorded by the source corpus.

Subfields: Ecology, Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. I. Samish
2. William F. DeGrado
3. I. Korendovych

In Materials Chemistry

1. I. Samish
2. Sagar D. Khare
3. Sarel Jacob Fleishman
4. William F. DeGrado
5. I. Korendovych

In Molecular Biology

1. I. Samish
2. Sagar D. Khare
3. Sarel Jacob Fleishman
4. William F. DeGrado
5. I. Korendovych
6. David Baker
7. Tanja Kortemme

Citations in the corpus

• De novo protein design, a retrospective (2020, background): “14a); weaker end-to-end interactions can be used to induce intermonomer contacts in crystals (Ogihara et al., 1997; Lanci et al., 2012; Zhang et al., 2018b) In other examples of helical fibril engineering, the individual helices are designed to form lateral assemblies that run nearly perpendicular…”
• Achievements and Challenges in Computational Protein Design. (2017, methodology): “In 2012 the Saven and DeGrado labs applied CPD for designing a protein crystal [103].”
• Emerging themes in the computational design of novel enzymes and protein–protein interfaces (2013, methodology): “In two independent studies, large homo-olig-omeric complexes were generated by (1) docking of homotrimeric structures into larger assemblies consistent with a target symmetry, and (2) symmetric design of the resulting interfaces between trimers to optimize their binding affinity [57,58].”