Inflammatory bowel disease.

By A. Kaser, S. Zeissig, R. Blumberg. Annual Review of Immunology, 2010

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Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “stress and unfolded protein response ensure the correct functioning of protein trafficking, required for the proper functioning of highly secretory IEC types, such as goblet cells and Paneth cells, and highly phagocytic cells, such as macrophages (Kaser et al., 2010).”
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “Foxp3 directly interacts with RORγt to suppress its function, but IL-6, IL-21, and IL-23 downregulate the Foxp3-mediated suppression of RORγt [11, 191].”
Adiponectin Regulation and Function (2018, positive): “Goblet cells produce mucus, which plays a crucial role in intestinal homeostasis by overlaying the epithelial cells and preventing bacterial invasion and inflammation (131).”
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “IBD results from the complex interplay of Westernized lifestyle-associated environmental factors and genetic susceptibilities, culminating in uncontrolled immune responses against luminal triggers (Kaser et al., 2010).”