Post-transcriptional gene regulation by mRNA modifications

By B. Zhao, I. A. Roundtree, Chuan He. Nature reviews. Molecular cell biology, 2016

2,021 citations recorded by the source corpus.

The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation. N6-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses. Other mRNA modifications, including N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine, together with m6A form the epitranscriptome and collectively code a new layer of information that controls protein synthesis.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ebb7cd70c35885357952e22b922d2ce8461407e8

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In Molecular Biology

1. R. Su
2. Jianjun Chen
3. Ying Yang
4. Hongbin Sun
5. Yun-Gui Yang
6. Phillip J Hsu
7. Yu-Sheng Chen
8. Huilin Huang

Citations in the corpus

• RNA N6-methyladenosine modification in cancers: current status and perspectives (2018, background): “A set of m(6)A demethylases, such as FTO and ALKBH5, can remove m(6)A modification from RNA as m(6)A erasers and thus keep m(6)A modification in a dynamic balance.(6,7,17) Members of the YT521-B homology (YTH) domain family of proteins, including YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2, have been”
• YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “By reading and interpreting the m(6)A mark, these proteins play important roles in gene regulation, DNA repair, and cell fate determination [44].”
• Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation (2017, neutral): “Recent in vitro studies have identified multiple functions of m(6)A in mRNA metabolism, from processing in the nucleus to translation and decay in the cytoplasm (Zhao et al., 2017a).”
• RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 (2018, background): “In this regard, investigating the landscapes and functions of these reversible RNA modifications is now emerging as a new frontier of research known as RNA epigenetics or epitranscriptomics.((11)) Although these modifications have been known for decades, deciphering their biological roles remains ch”
• G3BP1 is a tunable switch that triggers phase separation to assemble stress granules (2020, neutral): “We exchanged the RBD of G3BP1 with five different classes of RBDs: the tandem RRMs from hnRNPA1 and hnRNPA2B1, the zinc finger motifs from RBM22 and ZC3H11A, the KH domains from NOVA and QKI, the YTH domains from YTHDF1, YTHDF2, and YTHDF3 (three proteins that specifically bind m6A-RNA (Zhao et al.,”
• Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “FUNCTIONS IN RNA METABOLISM Recent accumulative studies revealed that m(6)A methylation regulates almost every aspect of mRNA metabolism, from expression and pre-mRNA processing in the nucleus to translation and mRNA decay in the cytoplasm.(1,3,4,10,118) m(6)A has been reported to be associated with”