The hierarchy quorum sensing network in Pseudomonas aeruginosa
By Jasmine Lee, Lian-zhu Zhang. Protein & Cell, 2014
1,188 citations recorded by the source corpus.
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.
Subfields: Molecular Biology, Molecular Medicine, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/bc5fffc7bc2e6970e3fa37058cbe929795ee3430
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In Molecular Biology
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In Molecular Medicine
Citations in the corpus
- Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections (2016, background): “aeruginosa produces an impressive array of particularly secreted virulence factors, utilising its type III secretion system to secrete various exotoxins (ExoS, ExoU, ExoT, and ExoY) [75], and quorum sensing (QS) systems (cell-density-dependent regulation) to control numerous important secreted virul”
- Role and application of quorum sensing in anaerobic ammonium oxidation (anammox) process: A review (2021, background): “The expression of a particular gene often requires the concentrations of multiple signal molecules to reach a threshold at the same time, which makes some behaviors that transform bacteria only occur under certain conditions (Lee & Zhang, 2015; Williams & C amara, 2009).”
- Pseudomonas aeruginosa Biofilms (2020, background): “The LasR–3O-C12-HSL also induces the expression of rhlR and rhlI genes as well as the pqsR and pqsABCDH genes which encode the Rhl [82] and the PQS [88] systems, respectively.”
- RNA target highlights in CASP15: Evaluation of predicted models by structure providers (2023, background): “68 73 RsmZ is a small noncoding RNA that can bind to RsmA and modulate RsmA regulation.”
- Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “For example, in response to various nutritional and environmental stimuli, the regulatory relationship between Rhl and Pqs systems can change independently of Las.(170) The activation of QS genes generally requires a large number of regulatory factors to control receptor expression or function, and/”