Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells.

By M. Bachem, Marion Schünemann, Marco Ramadani, M. Siech, H. Beger, A. Buck, Shaoxia Zhou, A. Schmid‐Kotsas, G. Adler. Gastroenterology, 2005

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Cancer-associated stromal fibroblasts promote pancreatic tumor progression. (2008, background): “stellate cells have used cells isolated from rats (10, 11), with relatively few studies using primary HPSCs from pancreatic cancer (12, 13).”
Stromal biology and therapy in pancreatic cancer (2010, background): “55 In vivo, co-injection of PSCs and cancer cells results in increased tumour growth accompanied by a pronounced desmoplastic reaction.(55) 56 A recent study using an orthotopic tumour model with co-cultured PSCs and pancreatic cancer cells showed increased migratory potential in both cell types but”
The pancreatic stellate cell: a star on the rise in pancreatic diseases. (2007, background): “Furthermore, pancreatic tumor cells induce the proliferation of PaSCs by secreting PDGF and induce PaSC production of ECM proteins by secreting TGF-β 1 and FGF-2 (84).”