Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

By R. Tukey, C. Strassburg. Annual Review of Pharmacology and Toxicology, 2000

1,568 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Pediatrics, Perinatology and Child Health, Surgery

View Paper: https://www.semanticscholar.org/paper/eb344593fe5692b0c585d22d2f5e76463ee2e7a1

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Citations in the corpus

• Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats (2010, background): “The gastrointestinal tract, liver, and kidneys possess high levels of Phase II metabolizing activities [14, 39]; resveratrol has been reported to undergo rapid and extensive glucuronidation and sulfation, and the gastrointestinal tract may be the major site for its metabolism [13, 19].”
• A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana. (2001, background): “In many higher organisms (D. melanogaster, C. elegans, Homo sapiens), this enzyme family is also very abundant and implicated in detoxification processes by glucuronylation of lipophilic compounds ( Tukey and Strassburg, 2000 ).”
• Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “…(Banoglu, 2000; Weinshilboum et al., 1997), and UDP-glucuronosyltransferases (UGT) (Innocenti et aL, 2002; King et aL, 2000; Mackenzie et aL, 1997; Tukey and Strassburg, 2000), DT-diaphorase or NAD(P)H:quinone oxidoreductase (NQO) or NAD(P)H: menadione reductase (NMO) (Jaiswal, 1994; Kong et aL,…”
• Glycosylation in cellular mechanisms of health and disease. (2006, background): “It is useful to distinguish secretory and cytoplasmic glycosylation from glucuronidation, the latter being an enzymatic process linking a single glucuronic acid to bile salts and xenobiotics (molecules that are foreign to cells) (Tukey and Strassburg, 2000).”
• The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. (2013, background): “2) (Tukey and Strassburg, 2000; ackenzie et al., 2005).”
• Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk (2015, background): “UDP-glucuronosyltransferase (UGT) enzymes are localized to endoplasmic reticulum (ER) and catalyze glucuronidation, which is involved in the elimination of bilirubin, steroids, bile acids, toxic dietary components, and several drugs, including morphine, and irinotecan [60–61].”
• Complexity of dopamine metabolism (2013, background): “Glucuronidation is performed by ER-bound uridine diphosphoglucuronosyltransferases (UGTs) [139] transferring glucuronic acid from UDP-glucuronic acid to DA.”