Role of gut microbiota in type 2 diabetes pathophysiology
By M. Gurung, Zhipeng Li, H. You, R. Rodrigues, D. Jump, A. Morgun, N. Shulzhenko. EBioMedicine, 2020
1,442 citations recorded by the source corpus.
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D.
Subfields: Gastroenterology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/ea865e10a30a1d3da87e8fb6fa009d53b3e8a72b
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Citations in the corpus
- The Gut Microbiota and Inflammation: An Overview (2020, background): “In contrast, bacteria known to stimulate anti-inflammatory cytokines such as IL-10 and IL-22, have been associated with anti-diabetic effects in animal models [137].”
- Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “Associations between altered microbial composition and type 2 diabetes are more established, with decreased levels of butyrate‐ producing bacteria reported in type 2 diabetic patients (Gurung et al., 2020).”
- Human gut microbiota in health and disease: Unveiling the relationship (2022, background): “Recent studies have demonstrated that the progression of diabetes is closely correlated to the alterations in the composition of intestinal microbiota (Sender et al., 2016; Gurung et al., 2020).”