A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression

By B. Cohen, Robi David Mitra, J. Hughes, George M. Church. Nature Genetics, 2000

552 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ea5849bcbbf2734f1edbd8947268515e7974d351

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In Molecular Biology

Citations in the corpus

WebGestalt: an integrated system for exploring gene sets in various biological contexts (2005, background): “Nonetheless, recent studies in yeast (24), worm (25), fly (19,26), mouse (27) and human (28,29) suggest that gene location might not be random.”
Dynamic flux balance analysis of diauxic growth in Escherichia coli. (2002, background): “These parameters, however, can be estimated from biochemical parameters such as the transcription and translation rates and genomic information involving regulatory elements, microarray data, and proteomics (Tavazoie et al., 1999; Cohen et al., 2000; Kirkpatrick et al., 2001).”
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. (2011, background): “2008), since coexpression of chromosomal protein-coding gene neighbors was previously shown across eukaryotes (Cohen et al. 2000; Hurst et al. 2004).”
A new approach to decoding life: systems biology. (2001, background): “Alternatively, gene-expression data may be combined with information on protein-protein interactions and protein phylogenetic profiles (85) or augmented with the genomic location of each gene to find shared regulatory elements (32).”
The evolutionary dynamics of eukaryotic gene order (2004, background): “They found that 25% of genes with cell-cycle-dependent expression patterns were directly adjacent to genes induced in the same phase of the cell cycle (see also Ref”
Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development (2008, background): “Similar patterns of genome organization have also been observed in animals and fungi [21,22].”
Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. (2002, methodology): “Genes with low expression and low variance were filtered from the dataset as described (Cohen et al., 2000).”
Genetic analysis of genome-wide variation in human gene expression (2004, background): “Some sets of closely linked genes are influenced by the same cis regulators, and have correlated expression profile”
A proteomic view of the Plasmodium falciparum life cycle (2002, unknown): “Furthermore, mRNA analyses in Saccharomyces cerevisiae”
Cohesin relocation from sites of chromosomal loading to places of convergent transcription (2004, background): “This seems now unlikely to be generally the case, as neighbouring genes in budding yeast show a high probability of co-regulation, irrespective of whether they are oriented in divergent or convergent orientatio”