Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

By Derek C. Angus, W. Linde‐Zwirble, J. Lidicker, G. Clermont, J. Carcillo, Michael R. Pinsky. Critical Care Medicine, 2001

8,624 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/ea1534e7b05a242eff494b9c25743222d6a0e3ae

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In Critical Care and Intensive Care Medicine

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Citations in the corpus

The fetal inflammatory response syndrome. (2007, background): “SIRS and sepsis are the main causes of death of patients admitted to intensive care units, with mortality rates ranging from 30% to 70% despite more than 20 years of intensive basic and clinical research.(3,4) The original definition of SIRS in adults was proposed in 1992 by the American College of ”
AKI in Hospitalized Patients with COVID-19. (2020, background): “001 Mount Sinai Hospital located in East Harlem, Manhattan 1507 (38) 662 (36) 845 (39) Mount Sinai Morningside located in Morningside Heights, Manhattan 699 (18) 340 (19) 359 (17) Mount Sinai West located in Midtown and the West Side, Manhattan 480 (12) 167 (9) 313 (15) Mount Sinai Brooklyn located ”
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference (2003, background): “Approximately 150,000 people die annually in Europe and 200,000 die annually in the United States (18).”
Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. (2015, background): “Although the absolute number of pediatric severe sepsis cases has been reported as 10fold less than adults (4, 41), the 8.”
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation (2009, background): “Recent estimates indicate that the rate of severe sepsis hospitalizations doubled during the past decade, and the ageadjusted population-based mortality is increasing, resulting in at least 215,000 deaths in the United States yearly (1, 2).”
Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis (2010, positive): “Our findings, and the nationally representative data from the HRS, allow us to make an estimate of the overall public health burden of sepsis on “brain health” among older adults in the United States.”
Early Lactate Clearance is Associated with Improved Outcome in Severe Sepsis and Septic Shock (2004, background): “Approximately 51% of hospital admissions for severe sepsis require intensive care (21).”
International study of the prevalence and outcomes of infection in intensive care units. (2009, background): “Infection and related sepsis are the leading cause of death in noncardiac ICUs, with mortality rates that reach 60% and account for approximately 40% of total ICU expenditures.(1,5) Importantly, the incidence of sepsis is increasing, as is the number of consequent infection-related deaths.”
An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU (2017, background): “[1–4] Recent literature suggests that early and appropriate antibiotic therapy is the main factor predicting sepsis outcomes.”
Benchmarking the Incidence and Mortality of Severe Sepsis in the United States* (2013, methodology): “Patients identified using the methods of Angus et al (8) and Wang et al (12) were more likely to have single-organ system involvement (72.”
Hematologic changes in sepsis and their therapeutic implications. (2004, background): “In the United States alone, there are more than 800,000 cases of severe sepsis each year.(1) The mortality in patients with severe sepsis ranges from 28 to 50% or greater.”
Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach (2016, background): “Sepsis and its associated syndromes are among the leading causes of worldwide morbidity and mortality [1] and are responsible for placing an enormous cost burden on the health care system [2].”
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 (2024, neutral): “33 To calculate attributable years lived with disability (YLDs), we took the product of the infectious syndrome incidence (appendix 1 pp 27–32), the fraction of infectious syndrome incident cases attributable to each pathogen, YLDs per incident case, and the non-fatal PAF.”
Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007 (2012, methodology): “001 In-hospital Mortality Overall 75 (2) 83 (2) 89 (2) 86 (2) 87 (2) .”