Early Lactate Clearance is Associated with Improved Outcome in Severe Sepsis and Septic Shock

By S. Hughes. Critical Care Medicine, 2004

1,200 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

From vital signs to clinical outcomes for patients with sepsis: a machine learning basis for a clinical decision support system (2014, background): “20 21 Adults with sepsis and hyperlactatemia appear to have a lower mortality risk if diagnosed early and enrolled in a targeted resuscitative strategy programme.”
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine (2014, neutral): “associated with a decreased mortality rate [49].”
Etiology and therapeutic approach to elevated lactate levels. (2013, background): “0 mmol/L (depending on study design) within 24 hours have significantly better outcomes than patients whose elevated lactate levels persist.(28-32) Serial lactate level measurements may be useful in documenting treatment response to various therapeutic interventions (see below).”
Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. (2010, background): “Diagnostic category, (% of patients in the randomization group) Sepsis category 67 (38) 68 (40) Severe sepsis 39 (22) 30 (18) Septic shock 28 (16) 38 (22) Nonsepsis category 110 (62) 103 (60) Neurologic 19 (11) 18 (11) Cardiac arrest 24 (14) 24 (14) Other nonsepsis 67 (38) 61 (36) Hospital, n (% of ”