A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan Criteria

By Jiwei Huang, Lv-nan Yan, Zhe-Yu Cheng, Hong Wu, Li-Ping Du, Jinzhou Wang, Ying-long Xu, Yong Zeng. Annals of Surgery, 2010

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EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, result): “Two RCT have been reported with opposite results [272,273].”
Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update (2017, background): “criteria showed that OS and RFS were significantly lower in RFA than in surgical resection [485].”
A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. (2012, background): “reported that the 2-year recurrence rate of their RFA group was higher than that of their RES group [16].”
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, result): “Two RCT have been reported with opposite results [272,273].”
AASLD guidelines for the treatment of hepatocellular carcinoma (2018, background): “A subgroup analysis for outcomes of smaller single lesions was not performed by Weis et al.,(41) but examining the three individual RCT trials included in the systematic review, Huang et al.(42) demonstrated that survival following resection remained favorable compared with RFA (P 5 0.03) in patient”