Transcriptional Programs Define Molecular Characteristics of Innate Lymphoid Cell Classes and Subsets
By M. Robinette, A. Fuchs, V. Cortez, Jacob S. Lee, Yaming Wang, S. Durum, S. Gilfillan, M. Colonna. Nature Immunology, 2015
602 citations recorded by the source corpus.
The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2 and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear, and it remains controversial whether natural killer (NK) cells and ILC1 cells are distinct cell types. To address these issues, we analyzed gene expression in ILCs and NK cells from mouse small intestine, spleen and liver, as part of the Immunological Genome Project. The results showed unique gene-expression patterns for some ILCs and overlapping patterns for ILC1 cells and NK cells, whereas other ILC subsets remained indistinguishable. We identified a transcriptional program shared by small intestine ILCs and a core ILC signature. We revealed and discuss transcripts that suggest previously unknown functions and developmental paths for ILCs.
Subfields: Immunology, Surgery
View Paper: https://www.semanticscholar.org/paper/e9f6bfaee32dd7844f184ecf5ef85a6ef04020d5
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Citations in the corpus
- Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “more difficult in the spleen and small intestine (106).”
- Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types (2017, result): “In addition, and in line with previous reports 21,22 , (co-)expression of CD127 with CD27, CRTH2, and c-KIT revealed the phenotypes corresponding to helper-like ILC type 1, 2 and 3, respectively (indicated by arrows in Fig.”