Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

By S. Hayami, John D. Kelly, Hyun-soo Cho, Masanori Yoshimatsu, M. Unoki, Tatsuhiko Tsunoda, Helen I. Field, David E. Neal, H. Yamaue, Bruce A. J. Ponder and 2 more. 2011

455 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

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Citations in the corpus

Late Cornified Envelope Group I, a Novel Target of p53, Regulates PRMT5 Activity (2014, background): “Current progress of molecular medicine revealed that the enzymes relevant to histonemethylation play critical roles in human carcinogenesis [28,35–45].”
TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “Both LSD1 and MMSET are expressed in solid tumors such as breast tumors at higher levels than in normal epithelial cells [29,30].”
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents (2015, methodology): “Cell cycle analysis was conducted as previously described [46–50].”
The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells. (2014, methodology): “The pCAGGS-SMYD2-HA or empty pCAGGS-HA mock vector was transfected into HeLa cells by FuGENE6 (Roche Applied Science, Penzberg, Germany) according to the manufacturer's protocol [22,33], and the antibiotics-resistant clones were selected with the culture media containing 0.”
The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, methodology): “Flow cytometry assays (FACS) for cell cycle analysis A 5’-bromo-2’-deoxyuridine (BrdU) flow kit (BD Pharmingen, San Diego, CA) was used to determine the cell cycle kinetics and to measure the incorporation of BrdU into DNA of proliferating cells.(24) The assay was performed according to the manufact”
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. (2014, methodology): “293T cells were co-transfected with a FLAGSMYD2 expression vector and four different lengths of HA-HSP90AB1 vectors ([1–724], [1–500], [250–724] and [500–724]).”
The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop (2015, background): “LSD1 levels have been shown to be particularly important determinants in bladder cancer growth and patient outcome (48).”
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1 (2016, unknown): “The 5’-bromo-2’-deoxyuridine (BrdU) flow kit (BD Biosciences) was used to determine the cell cycle kinetics and to measure the incorporation of BrdU into DNA of proliferating cells [37, 55–58].”
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, methodology): “LSD1 is highly expressed in multiple types of cancer, including bladder cancer, oestrogen-receptornegative breast cancer, colorectal cancer, lung cancer and prostate cancer [16, 17, 38].”