Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

By Ethan D. Buhr, Seung-Hee Yoo, J. Takahashi. Science, 2010

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How researchers see this paper

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Neural Circuitry of Wakefulness and Sleep (2017, positive): “Additionally, circadian oscillations in kinase pathways, energy metabolism (AMP/ATP ratio), and redox state (NAD+/NADH ratio) link global control of cellular physiology and metabolism to the molecular clock. cells and tissues without affecting its own timekeeping (Buhr et al., 2010).”
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences and Countermeasures (2016, neutral): “nizing effects on oscillators throughout the body (106).”
Molecular Architecture of the Mammalian Circadian Clock (2013, background): “This master clock is the only molecular clock to receive light input from the retina that synchronizes internal clock timing to the external solar day, which it passes on to peripheral clocks via endocrine and systemic cues [6, 7].”
Molecular components of the Mammalian circadian clock. (2013, background): “In our own work, we observed an impairment in temperature compensation of PER2 rhythms in the SCN and pituitary of mice when the heat shock factors (HSF) were pharmacologically blocked (Buhr et al. 2010).”
CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “F or p er so na l u se o nl y. NAD: nicotinamide adenine dinucleotide oscillators (Buhr et al. 2010).”