Measurement of mechanical tractions exerted by cells in three-dimensional matrices

By W. Legant, Jordan S. Miller, Brandon L. Blakely, Daniel M. Cohen, G. Genin, Christopher S. Chen. Nature Methods, 2010

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Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, methodology): “Images in the Figure were adapted with permission from Grinnell et al., 2003 (A), Doyle et al., 2009 (C) and Legant et al., 2010 (D) (Grinnell et al., 2003; Doyle et al., 2009; Legant et al., 2010).”
Lattice Light Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution (2014, positive): “5F), and in the future these data might be combined with 3D traction force microscopy (41) to create high-spatiotemporal-resolutionmaps of the forces generated by the cells as they migrate through their surroundings.”
A Review of Cell Adhesion Studies for Biomedical and Biological Applications (2015, background): “Bead dispersion in the 3D gel will be observed to estimate the cellular contractility of the cell during migration [63–67].”
Hydrogels with tunable stress relaxation regulate stem cell fate and activity (2015, methodology): “The stress relaxation behavior for a Maxwell model with n elements in parallel is: σ = σ! ! e−t/τn (2) The stress relaxation data for the different alginate gels with an initial elastic modulus of 9 kPa were fit to simple Maxwell models and Maxwell-Weichert models with 2 Maxwell elements in parall”
A benchmark for comparison of cell tracking algorithms (2014, background): “The registered participants worked on the training datasets during the 4 weeks before the competition datasets were released.”