The GLUT4 glucose transporter.

By Shaohui Huang, M. Czech. Cell Metabolism, 2007

1,297 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/e8ced079607b0b361c3b2d9991bf2198374137e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Amirhossein Sahebkar
2. Habib Yaribeygi

In Molecular Biology

1. D. Fruman
2. B. Hopkins
3. R. Abraham
4. Honyin Chiu
5. S. Bagrodia
6. J. Luiken
7. Lewis C. Cantley
8. Carlo Reggiani

In Surgery

1. J. Luiken
2. A. Bonen
3. J. Glatz

Citations in the corpus

• Fiber types in mammalian skeletal muscles. (2011, background): “Insulin acts via the PI3KAkt pathway on a GTPase activating protein, TBC1D4/ AS160, and Rab proteins, while contraction acts mainly via the CaMKII and AMPK, which also act on TBC1D4/AS160 (357, 808).”
• The SLC2 (GLUT) Family of Membrane Transporters (2013, neutral): “…appears to be a tortuously complex subcellular trafficking pattern that likely involves the general endosomal pathway, specialized GLUT4 storage vesicles (GSVs), a subdomain of the treans-Golgi network, and probably the plasma membrane [reviewed in (Huang and Czech, 2007; Larance et al., 2008).”
• Insulin resistance: Review of the underlying molecular mechanisms (2018, background): “Insulin significantly increases hexokinase gene expression in GLUT‐4 and thereby aids glucose retention in cells (Hall, 2015; Huang & Czech, 2007).”
• Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “Several recent reviews discuss in detail the defects in postreceptor insulin signaling mechanisms (1, 194, 207, 428) that are at the root of fatty acid-induced insulin resistance in skeletal muscle and the heart in obesity and type 2 diabetes.”
• The PI3K pathway in human disease (2017, positive): “The immediate effect of insulin-driven PI3K signaling inmuscle and fat cells is an increase in glucose uptake, attributable to enhanced glucose transporter translocation to the membrane (Huang and Czech, 2007) as well as increases in transcription and translation of the genes encoding these transpor”
• Gut Microbiota and Immune System Interactions (2020, background): “Insulin also promotes glucose uptake by stimulating translocation of the principal glucose transporter (GLUT4) to the plasma membrane in skeletal muscle and adipose tissue [85].”