Nanoparticles target distinct dendritic cell populations according to their size
By V. Manolova, A. Flace, M. Bauer, K. Schwarz, P. Saudan, M. Bachmann. European Journal of Immunology, 2008
1,245 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/e8b8eb9469e38d40bd1b6d8845f106e23fc76324
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
Citations in the corpus
- Engineering virus-like particles as vaccine platforms (2016, neutral): “Interactions with specific receptors on or within immune cells [1 ,27], interactions with molecules that influence trafficking [2 ], the intrinsic half-life of particles, and compatibility with adjuvants can all have effects on the magnitude and longevity of immune responses, and the specific arms o”
- Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “[131] reported that fluorescent polystyrene particles traffic to draining lymph nodes in mice in a sizedependent manner.”
- Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “Instead, large particles need to be carried into the lymphatic system by specialized cell”
- Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “By mimicking this size-dependent transport process, synthetic polymer particles that carry antigens and are”
- Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. (2017, positive): “showed that upon injection into mice, 20 nm polystyrene beads localized in the SCS and B cell areas while larger particles were excluded from the SCS and found in areas more distal from B cell follicles.(27) In contrast, other studies employing state-of-the-art visualization techniques have suggeste”
- Control of Polymeric Nanoparticle Size to Improve Therapeutic Delivery (2015, background): “3 Factors to Consider in NP-size Lymph Node Targeting Studies—Though studies do not identify an exact optimal size, results suggest that the NP size for most efficient interstitial transport is between 20 and 50 nm and that larger particles only later reach the LNs by dendritic cell (DC) transport [”
- PLGA-based nanoparticles: an overview of biomedical applications. (2012, background): “Nanoparticles smaller than 200 nm can reach the lymphoid organs directly within hours after injection, while particles larger than 200–500 nm require APCs, which will take approximately 24 h to arrive in the lymph nodes [61].”
- Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction (2012, background): “injection sites to dLNs for at least 8 d (29).”