Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor

By Aaron W. McGee, Yupeng Yang, Quentin S. Fischer, N. Daw, S. Strittmatter. Science, 2005

671 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/e8a8dcccd14a1a0aafb1c9181c52bb8e34208d06

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology (2021, positive): “Myelination of the cortex restrains further axonal and dendritic plasticity (McGee et al., 2005), as myelin-associated proteins inhibit neurite outgrowth.”
White matter in learning, cognition and psychiatric disorders. (2008, positive): “[78]. In laboratory animals in which the gene for the Nogo-66 receptor is eliminated, the critical period for ocular dominance plasticity, normally 20‐33 days postnatal in mice, is extended well into adulthood (45‐120 days) [ 79 ].”
Myelination and support of axonal integrity by glia (2010, background): “NGR mutants exhibit a longer critical period, in which ocular dominance columns can be reshaped in the visual corte”
Trends and Properties of Human Cerebral Cortex: Correlations with Cortical Myelin Content (2013, positive): “There is now a considerable amount of molecular evidence that factors associated with myelin inhibit both new axonal growth and synapse formation (Chen et al., 2000; Kapfhammer and Schwab, 1994; McGee and Strittmatter, 2003; McGee et al., 2005; McKerracher et al., 1994), which may reduce the plastic”
Adolescent neurodevelopment. (2013, background): “Myelination is thought to be one of the negative regulators of plasticity, raising the possibility that experience-related increases in myelination may serve to stabilize relevant axonal pathways at the cost of their further plasticity (79).”
Critical periods in speech perception: new directions. (2015, background): “Molecular brakes on plasticity eventually consolidate the neural circuit from a plastic to stable state, thereby closing the CP.”
Synaptic Mechanisms for Plasticity in Neocortex (2009, background): “F or p er so na l u se o nl y. receptor signaling, which enable spine plasticity and neurite outgrowth, reactivate ocular dominance plasticity in adults (Berardi et al. 2003, Hensch 2005, McGee et al. 2005).”
Removing brakes on adult brain plasticity: from molecular to behavioral interventions (2010, background): “1), such as myelin-related proteins inhibiting axonal sprouting (NgR, PirB) (McGee et al., 2005; Syken et al., 2006) or chondroitin sulfate proteoglycans.”
Plasticity of the visual cortex and treatment of amblyopia. (2014, positive): “Mice lacking either Nogo-A or its receptor NgR display OD plasticity well into adulthood [14], but whether Nogo-A antibodies can restore visual cortex plasticity in adult wild type animals has not been tested yet.”
Heterochronous laminar maturation in the human prefrontal cortex (2025, unknown): “…(area a24; light blue), the dorsolateral prefrontal cortex (area 46; medium blue), and the primary motor cortex (area 4; dark blue). h ) Regional variability in the skewness of depth-dependent R1 profiles is highly correlated across the cortex between the developmental and high-resolution datasets.”