Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins

By W. Gray, S. Kepinski, D. Rouse, Ottoline Leyser, M. Estelle. Nature, 2001

1,413 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e873c03dd90370564c6a9341dc24848bd4e593ce

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In Molecular Biology

1. Jian‐Kang Zhu
2. M. Estelle
3. B. Bartel
4. David P. Bartel
5. Xiansheng Zhang
6. Yu-Bo Liu
7. Y. Su
8. A. Mallory

In Plant Science

1. Jian‐Kang Zhu
2. David P. Bartel
3. M. Estelle
4. B. Bartel
5. Cyril Zipfel
6. Jonathan D. G. Jones
7. S. He
8. A. Mallory

Citations in the corpus

• Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. (2003, background): “…ebf1 and ebf2 mu-stance, AUX/IAA proteins, a group of transcriptional re- pressors in auxin signaling, are degraded through a tants (this study) as well as the ebf1 ebf2 double mutants (Potuschak et al., 2003 [this issue of Cell]), indicatingubiquitin/proteasome pathway (Gray et al., 2001).”
• MicroRNA Directs mRNA Cleavage of the Transcription Factor NAC1 to Downregulate Auxin Signals for Arabidopsis Lateral Root Development (2005, background): “These signaling components are known to be required for auxin-mediated lateral root development (Timpte et al., 1994; del Pozo and Estelle, 1999; Gray et al., 2001; del Pozo et al., 2002).”
• The Arabidopsis F-Box Protein SLEEPY1 Targets Gibberellin Signaling Repressors for Gibberellin-Induced Degradation (2004, methodology): “TIR1, COI1, EBF1, EBF2, andUFO have been shown to exist as components of SCF E3 complexes (Gray et al., 2001; Xu et al., 2002; Guo and Ecker, 2003; Potuschak et al., 2003;Wang et al., 2003).”
• The Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010827. (2003, background): “SCFTIR1 controls AXR2/IAA7 stability and is the only SCF in Arabidopsis for which a target has been identified to date (Gray et al., 2001).”
• Auxin: a trigger for change in plant development. (2009, neutral): “them for proteolysis (Gray et al., 2001).”
• Functional Genomic Analysis of the AUXIN RESPONSE FACTOR Gene Family Members in Arabidopsis thaliana: Unique and Overlapping Functions of ARF7 and ARF19w⃞ (2005, background): “The Aux/IAAs are targets for degradation by the SCFTIR1 complex, and most importantly, auxin mediates their interaction with the proteolytic machinery (Gray et al., 1999, 2001; Ward and Estelle, 2001; Dharmasiri and Estelle, 2004).”
• MicroRNA-Directed Regulation of Arabidopsis AUXIN RESPONSE FACTOR17 Is Essential for Proper Development and Modulates Expression of Early Auxin Response Genesw⃞ (2005, background): “TIR1 is the specificity component of an SCF E3 ubiquitin ligase that targets Aux/IAA proteins for ubiquitin-dependent degradation in response to auxin (Gray et al., 1999, 2001).”
• F-Box Proteins in Rice. Genome-Wide Analysis, Classification, Temporal and Spatial Gene Expression during Panicle and Seed Development, and Regulation by Light and Abiotic Stress1[W][OA] (2007, background): “Recently, it has been demonstrated that many F-box proteins, including TIR1, which has been known for a long time to regulate the stability of Aux/ IAA proteins, act as auxin receptors in Arabidopsis (Gray et al., 2001; Dharmasiri et al., 2005a, 2005b; Kepinski and Leyser, 2005).”
• Growth-defense tradeoffs in plants: a balancing act to optimize fitness. (2014, positive): “When auxin concentration reaches a threshold in the cell, auxin directly facilitates SCFTIR1/AFB binding to AUX/IAA proteins, resulting in the ubiquitination and degradation of AUX/ IAA repressors via the 26S proteasome thereby derepressing ARF-dependent transcription of auxin-regulated genes (Kepin”
• EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. (2003, background): “Indeed, it has been demonstrated that auxin stimulates the binding of the SCFTIR1 to the AUX/IAA proteinsSummary leading to their degradation (Gray et al., 2001).”