Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

By G. Nagel, T. Szellas, W. Huhn, S. Kateriya, Nona Adeishvili, Peter Berthold, D. Ollig, P. Hegemann, E. Bamberg. 2003

2,581 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Endocrine and Autonomic Systems

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Citations in the corpus

Neuron-type specific signals for reward and punishment in the ventral tegmental area (2012, background): “To identify dopaminergic neurons, we expressed channelrhodopsin-2 (ChR2), a light-gated cation channe”
Structural Properties of the Caenorhabditis elegans Neuronal Network (2009, background): “A similar calculation could be done for artificial stimulation of the neuronal network, induced for example, using channelrhodopsin [26,61,62].”
Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene (2004, methodology): “This supports the conclusions drawn by Nagel et al., 2003, that ChR2 might be a photoreceptor, being of importance only if cells are facing a long period of darkness.”
Motor control in a Drosophila taste circuit (2009, background): “Channelrhodopsin2 (ChR2) is a light-activated cation channel derived from the green alga Chlamydomonas renhardtii (Nagel et al., 2003).”
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics (2013, methodology): “However, the GCaMP excitation spectrum overlaps the action spectra of commonly used activators and silencers, such as channelrhodopsin-2 (ChR2) (Nagel et al., 2003, 2005; Boyden et al., 2005), archaerhodopsin-3 (Arch) (Chow et al., 2010), and halorhodopsin (HR) (Zhang et al., 2007).”
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures (2010, background): “At present, light-activated cation channels from two distinct algal species, channelrhodopsin-2 from Chlamydomonas reinhardtii (ChR2”
The Development and Application of Optogenetics (2011, background): “The desensitized population can recover in the dark with a characteristic time constant on the order of 5 seconds, giving rise to a similar peak photocurrent if a second light pulse is applied after sufficient time has elapsed (Nagel et al. 2003).”