Target mimicry provides a new mechanism for regulation of microRNA activity

By J. Franco-Zorrilla, Adrian A. Valli, M. Todesco, I. Mateos, María Isabel Puga, I. Rubio-Somoza, A. Leyva, Detlef Weigel, J. García, J. Paz-Ares. Nature Genetics, 2007

1,938 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/e81c863466c0a0b341b52bf73d23b6aa92cc946d

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Citations in the corpus

Long noncoding RNAs: functional surprises from the RNA world. (2009, methodology): “This target mimicry mechanism is used by the long ncRNA IPS1 (INDUCED BY PHOSPHATE STARVATION 1) in Arabidopsis thaliana (Franco-Zorrilla et al. 2007).”
Abiotic Stress Responses in Plants: Unraveling the Complexity of Genes and Networks to Survive (2013, background): “This mechanism designated as target mimicry was first described in plants [145] and more recently discovered in animals [146] and expands the regulatory post-transcriptional gene expression network in which miRNAs are involved.”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “In 2007, a study in Arabidopsis thaliana found the non-coding RNA IPS1 to bind to the microRNA miR-399 and block its ability to regulate PHO2 mRNA (78).”
The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. (2009, positive): “In contrast, all leaves produced by plants in which the activity of miR156 was suppressed by constitutively expressing a transcript with non-cleavable miR156 target site (a target-site mimic, MIM156) (Franco-Zorrilla et al., 2007) resembled adult leaves.”
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp™ (2014, background): “Highly expressed site-containing RNAs, either found naturally or delivered as research reagents, can act as ‘‘sponges’’ to titrate miRNAs away from other normal targets (Ebert et al., 2007; Franco-Zorrilla et al., 2007; Mukherji et al., 2011; Hansen et al., 2013; Memczak et al., 2013).”
MicroRNAs and complex diseases: from experimental results to computational models (2019, neutral): “Methods to induce a loss of function of miRNAs represent a powerful functional genomics tool [49].”
The control of developmental phase transitions in plants (2011, background): “Experimental evidence that the miRNA recognition elements (MREs) of these transcripts are indeed responsive and functional is diverse and convincing (Franco-Zorrilla et al., 2007; Martin et al., 2010b; Park et al., 2005; Schwab et al., 2005; Shikata et al., 2009; Usami et al., 2009; Wang et al.,…”