Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

By Qi Chen, Lijun Sun, Zhijian J. Chen. 2016

2,038 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Public Health, Environmental and Occupational Health

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Wenshuai Wang
2. Tuo Li
3. Zhijian J. Chen
4. A. Ablasser
5. Anna Marie Pyle
6. J. Rehwinkel
7. Jing Wang
8. M. F. Gulen

In Infectious Diseases

1. Tuo Li
2. A. Ablasser
3. Zhijian J. Chen
4. Wenshuai Wang
5. Anna Marie Pyle

In Public Health, Environmental and Occupational Health

1. Tuo Li
2. Zhijian J. Chen

Citations in the corpus

• The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, background): “…is essential for effective host response to the most significant viral health threats impacting society today, including coronaviruses, influenza, flaviviruses, andmany more (Chen et al., 2016; Chiale et al., 2022; Diamond and Kanneganti, 2022; Fitzgerald et al., 2014;Madden and Diamond, 2022).”
• Targeting DNA damage response promotes anti-tumor immunity through STING-mediated T-cell activation in small cell lung cancer (2019, background): “In contrast, treatment with PTX (10 and 20 μmol/L for 48 hours) did not cause any appreciable change in the mRNA expression of IFNβ (Supplementary Fig.”
• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “Another study shows that cancer cells metastasizing to the brain can also use the cGAS–STI NG pathway to promote tumor progression (Chen et al., 2016a).”
• Circular RNA: metabolism, functions and interactions with proteins (2020, background): “This evolves as a defense mechanism against microbial infections, while cGAS activated by self-DNA triggers autoimmunity [162].”
• Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence (2017, positive): “Upon activation, cGAS synthesizes the second messenger molecule 2`3`cyclic GMP-AMP (cGAMP), which engages STING, thereby leading to the production of inflammatory cytokines, chemokines and type I interferons (IFNs) 19 20 21 22, 23 24 25.”