Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review).

By G. Bertin, D. Averbeck. Biochimie, 2006

953 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/e802a2305ab02e7988bc0154191e138e68be2b88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Inna M. Sokolova
2. J. Ma
3. G. Lannig
4. A. Valavanidis
5. H. Pörtner

In Plant Science

1. J. Ma
2. Naoki Yamaji
3. Masahiro Yano
4. N. V. van Straalen
5. S. Hartley
6. F. Zhao
7. J. Cooke
8. M. Leishman

Citations in the corpus

• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “ROS-induced alteration of gene expression can occur through a modulation of a host of signaling pathways including cAMP-mediated cascades, calcium-calmodulin pathways, and intracellular signal transducers such as nitric oxide (Shi, Shi, and Liu 2004; Bertin and Averbeck 2006).”
• Flow cytometric analysis of the cadmium-exposed green alga Chlamydomonas reinhardtii (Chlorophyceae) (2009, background): “The production of ROS and oxidative damage may be associated with cadmium toxicity and large increases in lipid peroxidation have been demonstrated in several kinds of tissues in several types of organisms (Hassoun & Stohs, 1996; Bertin & Averbeck, 2006).”
• Cadmium stress: an oxidative challenge (2010, neutral): “many organisms (Bertin and Averbeck 2006; Thévenod 2009), which might result in physiological damage to different organs among which kidneys, liver, lung, pancreas, testes, placenta, and bone (Jarup et al.”
• Cellular mechanisms of cadmium-induced toxicity: a review (2014, background): “…different other possible indirect mechanisms have also been proposed to explain cadmium carcinogenesis, including oxidative stress, proto-oncogene activation, altered DNA methylation and dysregulated gene expression (Beyersmann and Hechtenberg 1997; Bertin and Averbeck 2006; Joseph 2009).”
• Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates. (2012, background): “…stress, UV radiation, metals and xenobiotics induce elevated ROS generation above the normal background levels and thus require energy-costly upregulation of antioxidant defenses (Winston and Giulio, 1991; Valko et al., 2005; Bertin and Averbeck, 2006; Abele et al., 2007; Kakkar and Singh, 2007).”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Moreover, alterations of DNA methylation induced by Cd exposure may cause aberrant expression of some genes important in apoptotic mechanisms (Deckert, 2005; Bertin and Averbeck, 2006).”
• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “intracellular signal transducers of nitric oxide (NO·) [147].”
• Gene limiting cadmium accumulation in rice (2010, background): “In humans, Cd exposure has been associated with cancers of the prostate, lungs, and testes, kidney tubule damages, rhinitis, emphysema, osteomalacia, and bone fractures (1, 2).”
• The Effects of Cadmium Toxicity (2020, methodology): “Using this method, cadmium can inhibit DNA repair, including nucleotide and base excisions and mismatch [131].”
• Molecular mechanisms of heavy metal tolerance and evolution in invertebrates (2009, background): “The generation of oxidative stress and subsequent lipid peroxidation of the cell membrane are to be ascribed to disruption of mitochondrial oxidative phosphorylation and the depletion of antioxidant protein pools (Korsloot et al., 2004; Bertin & Averbeck, 2006).”