Amyloid β-protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies
By Jessica Nasica-Labouze, P. Nguyen, Fabio Sterpone, O. Berthoumieu, Nicolae-Viorel Buchete, S. Côté, Alfonso De Simone, Andrew J. Doig, P. Faller, Ángel García and 14 more. Chemical Reviews, 2015
548 citations recorded by the source corpus.
Graphical abstract
Subfields: Molecular Biology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/e7fb3ec79ab0a3a5c6f8400dcb7d5c8df692baca
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Citations in the corpus
- Molecular dynamics simulations and novel drug discovery (2018, background): “It is reported that Aβ1-40 is mostly sensitive to mutations at positions 22 and 23, while Aβ1-42 is most affected by A21G [40,41].”
- Oxidative stress and the amyloid beta peptide in Alzheimer’s disease (2017, background): “Mutations of several genes (including PSEN1 and PSEN2) coding for APP, Presenilin 1 and Presenilin 2 (two sub-units of γ-secretase), identified as causative genes, have been found to cause mainly early-onset AD, while ApoE (involved in Aβ clearance) is considered as being the most common high geneti”