Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
By A. Könner, R. Janoschek, L. Plum, Sabine D. Jordan, E. Rother, Xiaosong Ma, Chun Xu, P. Enriori, B. Hampel, G. Barsh and 4 more. Cell Metabolism, 2007
685 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/e7ddd8e870fd069ddc965e494fae28ad2927e493
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrine and Autonomic Systems
In Molecular Biology
In Surgery
Citations in the corpus
- Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity (2017, positive): “Activation of insulin receptors on POMC neurons causes membrane hyperpolarization and reduced firing of these neurons (Könner et al., 2007; Williams et al., 2010) while increasing POMC mRNA expression (Benoit et al., 2002).”
- Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism (2010, positive): “Our understanding of insulin signaling in various tissues has been profoundly altered by the analysis of mutant mouse strains lacking the insulin receptor in only one cell type (Bluher et al., 2002; Bruning et al., 1998; Konner et al., 2007; Kulkarni et al., 1999; Michael et al., 2000).”
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “In the brain, this appears to involve IRs specifically in the AgRP neurons (37,65,67).”
- Energy Metabolism in the Liver (2014, positive): “AgRP neuron-specific deletion of insulin receptors blocks the ability of central insulin to suppress HGP (120).”
- The PI3K/AKT pathway in obesity and type 2 diabetes (2018, background): “Another way to regulate HGP is PI3K-stimulated generation of PIP3 in AgRP neurons, which activates K (ATP) channels, decreasing G6PC expression in the liver [91].”