Understanding the mechanisms and treatment options in cancer cachexia

By K. Fearon, J. Arends, Vickie E. Baracos. Nature Reviews Clinical Oncology, 2013

868 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/e7d6953c4a09cea2e8ef02deb7081061b1b115ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. P. Calder
2. P. Vaupel
3. E. Wagner

In Physiology

1. P. Calder
2. Vickie E. Baracos
3. P. Vaupel
4. D. McMillan
5. R. Zechner
6. C. Roxburgh

In Rheumatology

1. S. Rose‐John

Citations in the corpus

• Diagnostic criteria for the classification of cancer-associated weight loss. (2015, background): “Overweight and obesity are now prevalent worldwide,(6) and the upward shift in body weight renders definitions of clinically significant WL in patients with cancer increasingly unclear.(7,8) Cancer cachexia contributes to poor prognosis through progressive depletion of the body’s energy and protein ”
• A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. (2014, methodology): “A combination of reduced food intake and abnormal metabolism characterizes the pathophysiology of cachexia and determines the negative energy and protein balance (Fearon et al., 2013).”
• ESPEN expert group recommendations for action against cancer-related malnutrition. (2017, background): “Cytokines can affect the neuroendocrine control of appetite, leading to anorexia [23].”