HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

By A. Sáez-Cirión, C. Lacabaratz, O. Lambotte, P. Versmisse, A. Urrutia, F. Boufassa, F. Barré-Sinoussi, J. Delfraissy, M. Sinet, G. Pancino and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

637 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/e7595d06cb4c087b25fd898021a8c3a0587933e2

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Citations in the corpus

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, positive): “More recently, the ability of CD8 T cells of LTNPs to diminish HIV replication in humanized mice or in vitro was used as a measure of suppression of HIV replication (de Quiros et al., 2000; Saez-Cirion et al., 2007).”
Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study (2013, methodology): “We then examined the capacity of CD8+ T cells from the PTCs to suppress ex vivo the HIV-1 infection of autologous CD4+ T cells, as we recently showed that this test distinguishes the effective CD8+ T-cell responses found in many HICs from the ineffective responses in other patients [22].”
Stimulation of HIV-1-specific cytolytic T-lymphocytes facilitates elimination of latent viral reservoir after virus reactivation (2012, neutral): “Clinical studies of valproic acid, which has histone deacetylase (HDAC) inhibitor activity, have not shown a consistent decrease in the latent reservoir (Lehrman et al., 2005; Steel et al., 2006; Siliciano et al., 2007; Archin et al., 2008, 2010; Sagot-Lerolle et al., 2008).”