Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease
By H. Schunkert, Inke R. König, Sekar Kathiresan, M. Reilly, Themistocles L. Assimes, H. Hólm, Michael H. Preuss, A. Stewart, M. Barbalić, C. Gieger and 157 more. Nature Genetics, 2011
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We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10−8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
Subfields: Genetics
View Paper: https://www.semanticscholar.org/paper/e74a41b25fc435fd3a8756315a59b0cd168f7478
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In Genetics
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Citations in the corpus
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- An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans (2017, methodology): “Comparison between HapMap and 1000G reference variant sets We made LocusZoom(11) regional plots of the Stage 1 meta-analysis results indexed by lead SNV for the 13 novel loci, and estimated LD using the EUR 1000G March 2012 variant set (Supplementary Figure 2).”
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- Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods (2015, methodology): “Genetic associations with CHD risk were taken from the CARDIoGRAM consortium [48] and can be downloaded from http://www.”