Making polymeric micro- and nanoparticles of complex shapes

By J. Champion, Y. Katare, S. Mitragotri. Proceedings of the National Academy of Sciences of the United States of America, 2007

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A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics (2012, positive): “2 Particle Shape—Development of novel particle fabrication methods that allow for precise control over particle shape and size (Caldorera-Moore et al., 2011a; Champion et al., 2007; Glangchai et al., 2008; Rolland et al., 2005) has allowed for researchers to explore the effects of particle shape on ”
Intravascular Delivery of Particulate Systems: Does Geometry Really Matter? (2008, background): “More recently the effect of particle shape has been also considered by Mitragotri and his collaborators ( 16 )f or micrometer polystyrene particles phagocytosed by macrophages, and by Chan and his group (39) for gold nano-rods internalized by HeLa cells.”
Physical approaches to biomaterial design (2009, methodology): “For example, methods have been developed for fabricating polymeric particles with controlled shap”
Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, background): “The heating temperature required to deform the particles is determined by the glass transition temperature of the polymeric carrier, which is around 90°C for PLGA and 140°C for polystyrene (PS) [195].”