A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

By R. G. Perez, J. Waymire, Eva Lin, Jen-Jane Liu, Fengli Guo, M. Zigmond. Journal of Neuroscience, 2002

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How researchers see this paper

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Complexity of dopamine metabolism (2013, background): “α-Synuclein is a small protein ubiquitously present in the brain [158] and a negative regulator of DA biosynthesis due to interaction with TH [85].”
Tyrosine Hydroxylase and Regulation of Dopamine Synthesis (2010, background): “TyrH has been detected in complex with PP2A, AADC, GTPCH, VMAT and DJ-1.”
Neurodegenerative diseases and oxidative stress (2004, background): “and that α-synuclein can regulate dopamine synthesis by inhibiting tyrosine hydroxylas”
α-Synuclein in Parkinson's disease. (2012, background): “a-Synuclein is quite promiscuous in its binding properties, and may bind various proteins in neuronal cells, including components of dopamine metabolism, such as tyrosine hydroxylase (TH) and the dopamine transporter (DAT), modulating their function (Ostrerova et al. 1999; Perez et al. 2002; Wersing”
Helix periodicity, topology, and dynamics of membrane‐associated α‐Synuclein (2005, background): “aS can also block dopamine synthesis by inhibiting tyrosine hydroxylase (Perez et al. 2002).”
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? (2003, background): “The intracellular levels of dopamine may also be regulated by the direct interaction of α-synuclein with tyrosine hydroxylase, the rate-limiting step in dopamine biosynthesis (64).”