Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant

By Ana Traven, J. Wong, Deming Xu, M. Sopta, C. Ingles. 2004

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A mitochondrial specific stress response in mammalian cells (2002, background): “Evidence for such communication comes from the substantial changes in gene expression pro®les in r° yeast cells that have had their mtDNA removed (Traven et al., 2001).”
The environmental stress response: a common yeast response to diverse environmental stresses (2003, background): “Consistently, many of the genes involved in tRNA processing, and almost all of the genes encoding cytosolic aminoacyl tRNA synthetases, are repressed as part of this program.”
Cancer as a metabolic disease (2010, background): “Mitochondrial dysfunction also increases levels of cytoplasmic calcium, the multi-drug resistance phenotype, production of reactive oxygen species, and abnormalities in iron-sulfur complexes, which together would further accelerate aberrant RTG signaling and genome mutability [85,106,107,110,111,120”