Role of DNA mismatch repair defects in the pathogenesis of human cancer.

By P. Peltomäki. Journal of Clinical Oncology, 2003

723 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e69046c98a49ec400c50adb5a43470e95c5d72b0

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In Genetics

1. Debora Marks
2. Yarin Gal
3. J. Jiricny

In Oncology

1. J. Jiricny

In Pathology and Forensic Medicine

1. J. Jiricny

Citations in the corpus

• The multifaceted mismatch-repair system (2006, background): “jpg" NDATA ITEM> ]> Over the past decade, a significant proportion of cancers of the colon, endometrium and other organs were found to exhibit a phenotype known as microsatellite instability (MSI; see Ref”
• Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN and FOCUS studies (2014, neutral): “It has been suggested that a greater immunoreactivity of dMMR tumors (29, 30) or decreased tumor cell viability due to excessive DNA damage (31) may play a role.”
• Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning (2020, background): “Similarly, variants in MSH2 and MSH6 of the mismatch DNA repair complex are associated with hereditary nonpolyposis colorectal cancer 51 and with ~20% of sporadic cancers 52 , but only 4% of observed variants have clinical labels (Extended Data Table 1).”