Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

By M. V. Stipdonk, E. Lemmens, S. Schoenberger. Nature Immunology, 2001

1,034 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e684afb1d3f9acdd6b1793c8c87ed14ac556e415

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Citations in the corpus

Translating innate immunity into immunological memory: implications for vaccine development. (2006, neutral): “…especially appear to begin a program of cell differentiation and proliferation within hours of exposure of the ‘‘parental’’ cell to antigenic stimulus that results in 7–10 cell divisions over the course of the next few days (Kaech and Ahmed, 2001; van Stipdonk et al., 2001; Mercado et al., 2000).”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “A single brief T cell receptor (TCR) stimulus (signal 1) combined with costimulation (signal 2) can induce an extended period of proliferation, acquisition of effector functions, and ultimately, memory CTL formation (Kaech and Ahmed, 2001; Mercado et al., 2000; van Stipdonk et al., 2001).”
Signals required for programming effector and memory development by CD8+ T cells (2006, background): “2), these results suggest that brief exposure to antigen and B7 initiates an autopilot program that drives cell division (23, 27), but clonal expansion is minimal and the cells do not acquire cytolytic function.”
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. (2007, background): “This is plausible because unlike CD8 + T cells (Kaech and Ahmed, 2001; Mercado et al., 2000; van Stipdonk et al., 2001), CD4+ T cells only continue to proliferate in the presence of pMHC (Obst et al., 2005).”