The double life of HMGB1 chromatin protein: architectural factor and extracellular signal

2001

354 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e67bec951ae0470912d881794394a2f5a3db5702

Citations in the corpus

• Alkylating DNA damage stimulates a regulated form of necrotic cell death. (2004, neutral): “In response to DNA damage, there is an active redistribution of the macrophage activator HMGB1 from the nucleus to the cytosol (Fig. 4A; Muller et al. 2001).”
• The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway (2002, positive): “Recent studies have shown that HMGB1, widely known as a nuclear protein (Bianchi and Beltrame, 2000), can also behave as a proinflammatory cytokine (Wang et al., 1999; reviewed by Müller et al., 2001).”
• High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity (2007, neutral): “HMGB1 is almost always present in the nucleus, although under specific circumstances, some cells contain it in the cytoplasm, on the external side of their plasma membranes, or in extracellular fluids (18).”
• Harmful molecular mechanisms in sepsis (2008, neutral): “HMGB1 was originally described as a transcription facto”