Genetic contribution to variable human CYP3A-mediated metabolism.

By J. Lamba, Yvonne S. Lin, E. Schuetz, K. Thummel. Advanced Drug Delivery Reviews, 2002

1,026 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e64801f95eb1066cc03f6d5b3fafe01d6e63cf03

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In Oncology

1. Y. Luqmani

Citations in the corpus

• Mechanisms of Drug Resistance in Cancer Chemotherapy (2005, background): “and is known to metabolise more than 120 different drugs. Hepatic expression of CYP3A4 is known to vary by more than 50-fold among individuals and in vivo CYP3A4 enzymatic function (drug clearance) varies by at least 20-fold. The genetic basis for this was reviewed by Lamba et al. [”
• Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction (2006, neutral): “In humans, several isoforms, such as CYP2C9 [16], -2C19 [16], -1A1 [17], -2B6, -2D6 [18], -3A4 [19] and -3A5 [20], have been demonstrated to be polymorphic.”