In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice.

By Zhuang Liu, Weibo Cai, Lina He, N. Nakayama, Kai Chen, Xiaoming Sun, Xiaoyuan Chen, Hongjie Dai. Nature Nanotechnology, 2020

1,421 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e61d93090e6ae45b4dafd0b8b158ee6110b70ca8

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Citations in the corpus

Nanomedicine in cancer therapy (2023, background): “93,94 For example, cyclic RGDfK peptide-functionalized nanoparticles have been shown to be capable of selectively delivering DOX to the α ν β 3 -expressing tumor vasculature, resulting in a 15-fold increase in anti-metastatic ef ﬁ cacy of the drug in an orthotopic model of renal cell carcinoma,…”
Drug delivery with carbon nanotubes for in vivo cancer treatment (2008, methodology): “As-grown HiPco SWNTs functionalized by PEGylated phospholipid (14, 18) were used, made by sonication of SWNTs in a water solution of phospholipid-PEG and centrifugation to remove large bundles and impurities.”
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009, background): “The biodistribution profile of our nanotube bioconjugates showed accumulation in different vital organs as also reported for nanotubes solubilized with PEG.(23,29)”
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, methodology): “In our lab, we developed bio-inert PEGylated SWNTs conjugated with antibodies as NIR fluorescent tags for selective probing of cell surface receptors [24].”
Carbon nanotubes as photoacoustic molecular imaging agents in living mice (2008, positive): “It is possible that single-walled carbon nanotubes, due to their unique high aspect ratio ( (cid:2) 1:100) and high surface area to volume ratio, are capable of minimizing RES uptake while having an increased afﬁnity for molecular targets due to multivalency effects 17 .”