Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.

By A. Algra, Peter M. Rothwell. The Lancet Oncology, 2012

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Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies (2022, background): “Equally, it has been established that the risk of CRC can be reduced by physical activity [75], regular aspirin consumption [76,77], and hormone replacement therapy [78], while certain studies have also found that consumption of milk and whole grains may help protect against CRC [74].”
Wnt/beta-catenin pathway: modulating anticancer immune response (2017, background): “Through inhibiting cyclooxygenase-2 (COX-2), aspirin decreases the availability of prostaglandin E2 (PGE2), therefore reducing WNT levels [78].”