Evidence for two types of brown adipose tissue in humans

By Martin E. Lidell, M. Betz, O. Leinhard, Mikael Heglind, Louise Elander, M. Slawik, T. Mussack, D. Nilsson, Thobias Romu, P. Nuutila and 5 more. Nature Medicine, 2013

653 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/e5d763cd8d91a0e7a2d3dcb4057c113048f56836

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Gerald I. Shulman
2. Jun Wu
3. E. Wagner
4. P. Seale
5. B. Spiegelman
6. S. Kajimura
7. R. Kaufman

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. Jun Wu
5. P. Cohen
6. Gerald I. Shulman
7. Alexander Sakers
8. Mirian Krystel De Siqueira

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Gerald I. Shulman
5. L. Sidossis

Citations in the corpus

• A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. (2014, background): “Human brown fat is composed of adipocytes similar to both classical interscapular brown adipocytes (Cypess et al., 2013; Jespersen et al., 2013; Lidell et al., 2013) and mouse white adipocytes converted into brown (Sharp et al.”
• What We Talk About When We Talk About Fat (2014, neutral): “of human infants shares extensive similarity with classic brown fat in rodents (Lidell et al., 2013).”
• Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch (2014, background): “The kite-like structure in the interscapular region of human infants, however, seems to have characteristics of rodent classical BAT, and some classical brown fat cells may be retained in adult humans (Cypess et al., 2013; Jespersen et al., 2013; Lidell et al., 2013).”
• Adipose tissue plasticity in health and disease (2022, background): “Several groups have isolated populations of thermogenic adipocytes from adult humans: some report more transcriptional similarity to mouse beige adipocytes, while others report more similarity to mouse brown adipocytes (Jespersen et al., 2013; Lidell et al., 2013).”
• Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist (2015, background): “An intriguing issue is the proportional contribution by the two different brown adipocyte lineages: the constitutive ‘‘brown’’ adipocytes in the cervical and supraclavicular depots and the recruitable ‘‘beige/brite’’ adipocytes in the supraclavicular, abdominal, and other sites (Wu et al., 2012; Sha”
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “In humans, classical brown adipocytes exist in the interscapular BAT of infants (27).”