Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

By S. Prusiner, A. Woerman, Daniel A Mordes, J. Watts, R. Rampersaud, David B. Berry, Smita Patel, Abby Oehler, J. Lowe, Stephanie N. Kravitz and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2015

682 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e5c1e86b03fdea499e3eb419ddc3d50f2bb95132

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Sampson
2. S. Mazmanian
3. Rosa Krajmalnik-Brown
4. Justine W. Debelius
5. Z. Ilhan
6. Stefan Janssen
7. Rob Knight
8. Ali Keshavarzian

In Neurology

1. Brittany N. Dugger
2. Dennis W. Dickson
3. M. Hasegawa
4. M. Goedert

Citations in the corpus

• Structures of α-Synuclein Filaments from Multiple System Atrophy (2020, background): “characterise MSA and disorders with Lewy pathology (51-56).”
• Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease (2016, positive): “…diseases termed synucleinopathies, which includes PD, multiple system atrophy, and Lewy body disease (Brettschneider et al., 2015; Luk et al., 2012; Prusiner et al., 2015). aSyn aggregation is a stepwise process, leading to oligomeric species and intransient fibrils that accumulate within neurons.”
• Pathology of Neurodegenerative Diseases. (2017, background): “Some evidence supports that a-synuclein deposits within MSA have prion properties, as demonstrated by their trans- 14 Cite this article as Cold Spring Harb Perspect Biol 2016;9:a028035 missibility to transgenic mice and cultured cells (Watts et al. 2013; Prusiner et al. 2015).”