Myeloperoxidase-generated oxidants and atherosclerosis.

By E. Podrez, H. Abu-Soud, Stanley L. Hazen. Free Radical Biology & Medicine, 2000

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Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “MPO normally exists in the ferric (Fe III) form, although it undergoes different stages of activation depending on the ligands, O2 · or H2O2 (235).”
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. (2004, background): “MPO utilizes hydrogen peroxide (H2O2) and a variety of low–molecular weight organic and inorganic substances as substrates to form reactive oxidant species capable of promoting protein halogenation, nitration, and oxidative cross-linking (4, 5).”
Association between myeloperoxidase levels and risk of coronary artery disease. (2001, background): “Immunohistochemical studies have demonstrated the presence of MPO in human atherosclerotic lesions,(10) and mass spectrometry studies have shown that oxidation products generated by MPO are enriched in human atheroma and in low-density lipoprotein (LDL) recovered from diseased arterial tissue.(8,9,1”