Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule

By G. Ramage, S. Saville, B. Wickes, J. López-Ribot. Applied and Environmental Microbiology, 2002

705 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/e55bd3f2b1c5a3b5c56348bf2f3b5cdc9231bb18

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. G. Fleet
2. S. Saville
3. J. López-Ribot
4. J. Nosanchuk
5. D. Trofa
6. A. Gácser
7. K. Young
8. Paul Williams

In Molecular Biology

1. G. Fleet
2. S. Saville
3. J. López-Ribot
4. Robert Kolter
5. Deborah A. Hogan
6. Sivan Elias
7. E. Banin
8. K. Young

Citations in the corpus

• Engineered Control of Cell Morphology In Vivo Reveals Distinct Roles for Yeast and Filamentous Forms of Candida albicans during Infection (2003, methodology): “published bead beater protocol (28) and separated through a formaldehyde-”
• Candida parapsilosis, an Emerging Fungal Pathogen (2008, background): “albicans that inhibits biofilm formation as well as filamentation (115, 225).”
• Multi-species biofilms: living with friendly neighbors. (2012, background): “This transition is known to be essential for C. albicans biofilm formation (Ramage et al., 2002).”
• Essential Oils and Antifungal Activity (2017, background): “Tyrosol, an alcohol derived from tyrosine, has the opposite activity to farnesol, since it stimulates hyphal formation [127].”
• A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology (2004, background): “6) which has already been shown to inhibit filamentation and to decreased levels of HWP1 expression (Hornby et al., 2001; Oh et al., 2001; Ramage et al., 2002).”
• Microbial interactions within the plant holobiont (2018, neutral): “The latter secretes the signaling molecule farnesol to control filamentation [119, 120], to inhibit biofilm formation [121], and to activate oxidative stress responses or drug efflux [122, 123].”
• GENETIC CONTROL OF CANDIDA ALBICANS BIOFILM DEVELOPMENT (2010, neutral): “and, as might be expected, it inhibits biofilm formation in vitro”
• Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. (2013, background): “C. albicans has the capacity to switch from yeast morphology to hyphal morphology, one of its major virulence determinants (Lo et al., 1997; Ramage et al., 2002a).”
• Yeast interactions and wine flavour. (2003, background): “Recently, farnesol has been identified as a quorum sensing molecule that inhibits the transition of Candida albicans from the yeast to the hyphal stage and its ability to form biofilms (Hornby et al., 2001; Ramage et al., 2002).”