Abstract PR09: The prognostic landscape of genes and infiltrating immune cells across human cancers

By Andrew J. Gentles, Aaron M. Newman, C. Liu, S. Bratman, Weiguo Feng, Dongkyoon Kim, V. Nair, Yue Xu, Amanda Khuong, Chuong D. Hoang and 4 more. 2015

2,527 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e525c3811299de2a550006ad0fd5262e57ef25bd

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Citations in the corpus

Profiling tumor infiltrating immune cells with CIBERSORT (2018, background): “The significance of TILs varies by cancer histology, with the presence of certain immune subsets often exhibiting a beneficial prognostic effect in one malignancy but a detrimental effect in another cancer type [1,2].”
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells (2016, background): “Considerable efforts have been recently put in the development of sophisticated bioinformatics approaches that exploit lymphocyte gene-expression data to understand the immunemodulatory networks at tumor sites, to predict clinical responses to immune-therapies, and to define therapeutic targets (Bin”
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data (2017, background): “Therefore, to correctly interpret these data in particular from an immuno-oncology point of view (Angelova et al., 2015; Gentles et al., 2015; Hackl, Charoentong, Finotello, & Trajanoski, 2016; B. Li et al., 2016; Linsley, Chaussabel, & Speake, 2015; Rooney, Shukla, Wu, Getz, & Hacohen, 2015; Şenbab”
xCell: digitally portraying the tissue cellular heterogeneity landscape (2017, background): “Traditional approaches for dissecting the cellular heterogeneity in liquid tissues are difficult to apply in solid tumors [3].”
The head and neck cancer immune landscape and its immunotherapeutic implications. (2016, background): “In several other cancer types, Tregs have been associated with favorable prognosis (43).”
Gene expression markers of Tumor Infiltrating Leukocytes (2016, background): “The abundance and composition of the immune cells infiltrating a tumor predict both a patient’s prognosis [1-5] and the optimal immunotherapy for their disease [6].”
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions (2023, background): “Infiltrating neutrophils in the TME, known as tumor-associated neutrophils (TANs), promote cancer growth and is strongly associated with poor prognosis.(313) For instance, neutrophil-derived ROS damages hepatocyte DNA to drive HCC development.”
Exploration of prognosis-related microRNA and transcription factor co-regulatory networks across cancer types (2019, background): “These markers, either genetic or epigenetic, carry various indicative features and clues for further biological and clinical discoveries [3,4].”