Tread Lightly Interpreting Polygenic Tests of Selection
By John Novembre, N. Barton. 2018
97 citations recorded by the source corpus.
> In this issue of GENETICS, a new method for detecting natural selection on polygenic traits is developed and applied to several human examples ([Racimo et al. 2018][1]). By definition, many loci contribute to variation in polygenic traits, and a challenge for evolutionary geneticists has been that
Subfields: Genetics
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In Genetics
- Graham Coop
- Eli A. Stahl
- S. Myers
- J. K. Pritchard
- Chia-Yen Chen
- Alicia R. Martin
- L. Duncan
- Patrick F. Sullivan
Citations in the corpus
- A method for genome-wide genealogy estimation for thousands of samples (2019, background): “We also note that caution should be exerted when interpreting polygenic adaptation 54 .”
- Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. (2019, background): “Given current limitations in understanding similarities and differences in polygenic risk across populations, caution is advised in interpreting differences in PRSs across ancestries (Novembre and Barton, 2018).”
- Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies (2018, unknown): “Polygenic height scores and tSDS scores based on GIANT and UK Biobank GWAS.”
- Reduced signal for polygenic adaptation of height in UK Biobank (2018, background): “Thus our work highlights a need for caution in this area until these issues are more fully understood [2].”