Physical activity reduces the risk of subsequent depression for older adults.

By W. Strawbridge, S. Deleger, R. Roberts, G. Kaplan. American Journal of Epidemiology, 2002

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So depression is an inflammatory disease, but where does the inflammation come from? (2013, positive): “It is also evident that habitual or regular exercise protects against the development of new depressive illnesses [82-84], and that physical inactivity during childhood is associated with an increased risk of depression in adulthood [85].”
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “It is worth mentioning that exercise, which is an effective antidepressant in humans (Blumenthal et al., 1999; Strawbridge et al., 2002) and in rodent models (Bjornebekk et al., 2005; Greenwood et al., 2005), is also a potent stimulator of proliferation in the adult hippocampus (van Praag et al.,…”
Physical activity and older adults: a review of health benefits and the effectiveness of interventions (2004, background): “In contrast, Strawbridge et al. (2002) found a strong longitudinal protective effect for physical activity.”
Elderly travel frequencies and transport mode choices in Greater Rotterdam, the Netherlands (2016, neutral): “Subsequently, a circular buffer (see Wong et al. 2011) of 300 m around each residential location is computed and intersected with the averaged gridded environmental variables. Finally, during the length of the study period, daily meteorological data for the nearest weather station (‘Zestienhoven’ 51”