MR1 presents microbial vitamin B metabolites to MAIT cells
By L. Kjer-Nielsen, O. Patel, A. Corbett, J. L. Nours, Bronwyn S. Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, L. Kostenko, Rangsima Reantragoon and 10 more. Nature, 2012
1,283 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/1dd36e43656b8cf6466d3a37a9b7a197d9dae668
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Citations in the corpus
- Modeling T cell receptor recognition of CD1-lipid and MR1-metabolite complexes (2014, positive): “This is highlighted by a number of studies showing that, in addition to well-characterized recognition of peptide-major histocompatibility complex (pMHC) [1], many TCRs engage MHC-like molecules CD1, which present a variety of lipid antigens [2], and MR1, which presents vitamin B metabolites [3].”
- Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes (2015, background): “The gut-microbial production of riboflavin has been associated with the immune response through the activation of T-cells (Kjer-Nielsen et al., 2012).”
- IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection (2017, background): “Recently, innate-like mucosal-associated invariant T (MAIT) cells have been 102 identified and these recognise antigens derived from bacterial riboflavin (vitamin B2) 103 synthesis, which are presented by the non-polymorphic MHC-related protein 1 (MR1) [23].”
- Homeostatic immunity and the microbiota (2017, positive): “These cells are broadly reactive to bacterial and yeast species, because of their ability to recognize metabolic intermediates of the microbial riboflavin synthesis pathway (Kjer-Nielsen et al., 2012).”