Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.

By Anna Salvati, Andrzej S Pitek, M. Monopoli, Kanlaya Prapainop, F. B. Bombelli, Delyan R. Hristov, P. M. Kelly, Christoffer Åberg, Eugene Mahon, Kenneth A. Dawson. Nature Nanotechnology, 2013

1,724 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/844c878abccbca5e7923ca3a3ce4a19666c8aa63

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In Biomaterials

1. N. Bertrand
2. N. Kamaly
3. O. Farokhzad
4. Xiaoyang Xu
5. Liangfang Zhang
6. Jun Wu
7. T. Vandamme
8. J. Hanes

In Molecular Biology

1. O. Farokhzad
2. N. Bertrand
3. N. Kamaly
4. Xiaoyang Xu
5. Jun Wu
6. Liangfang Zhang
7. J. Hanes
8. L. Ensign

Citations in the corpus

• Insight into nanoparticle cellular uptake and intracellular targeting (2014, neutral): “[113] is of worth mentioning that reports disappearance of targeting ability of Tf functionalized nanoparticles in the biological media.”
• Nanoparticle biointerfacing via platelet membrane cloaking (2015, methodology): “0 μm carboxyl-functionalized polystyrene beads at a concentration of 4 wt% (Life Technologies) were functionalized with rabbit N-terminustargeted (extracellular) anti-human CD47 (Aviva Biosystems, ARP63284), rabbit intracellular-domain-targeted anti-CD47 (Genetex, EPR4150(2)), or rabbit anti-ovalbum”
• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “Thus, protein absorption not only reduces the circulation time, but also weakens the targeting capabilities of NPs functionalized for targeting specific cells [23].”
• Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, neutral): “96 Therefore, new strategies toward targeting speci fi c tissues need to be explored to address clinical challenges.”
• Protein-Nanoparticle Interactions (2013, background): “What is more, carbon nanotubes [41], nanorods [42, 43], nanowires [44], and semiconducting polymers [45] are used to develop sensors based on changes to gate conductance [46], hysteresis [47], or threshold voltage [48].”
• DLS and zeta potential - What they are and what they are not? (2016, background): “(2013) has shown that growth of protein corona on top of transferrin-functionalized silica NPs (~50 nm) eliminated their receptor-targeting capabilities [50].”
• An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “(3) The third phenomenon to be taken into account is the potential increase of the nanocarrier opsonisation due to the ligands.([46]) (4) Finally, the specific affinity between folic acid and liver could induce a premature hepatic uptake of the FA-decorated nanocarriers, after i.”