Silent brain infarcts and the risk of dementia and cognitive decline.

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Aggregation of vascular risk factors and risk of incident Alzheimer disease (2005, background): “Vascular risk factors are known to be related to stroke, and stroke has been shown to be associated with AD (26,58), but the mechanisms relating cerebrovascular disease to AD remain to be elucidated.”
The Rotterdam Study: 2010 objectives and design update (2007, background): “Possibly underlying this is that a large amount of stroke goes clinically undetected [201].”
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. (2003, background): “Furthermore, early AD and microinfarcts may interact in promoting probable dementia.54 Silent brain infarcts more than doubled the risk of dementia in 1015 participants (52% women) in the Rotterdam Scan Study.55 Autopsy data from the Nun Study56 support this hypothesis.”
Cerebral small-vessel disease and decline in information processing speed, executive function and memory. (2005, methodology): “On the basis of radiological findings strokes were further subdivided into haemorrhagic and ischaemic stroke subtypes (Vermeer et al., 2003).”
The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, neutral): “The Rotterdam Scan Study demonstrated that silent brain infarcts detected with MRI are associated with dementia in elderly people (Vermeer et al., 2003).”