Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy

By C. Xie, Yong-qing Li, Wei-Yao Tang, R. Newton. 2003

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Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157:H7 (2009, methodology): “Vibrational spectroscopic methods, such as Raman spectroscopy, have been applied extensively as rapid and noninvasive analytical techniques for monitoring and characterizing bacteria (Xie et al. 2003; Huang et al. 2004; Sengupta et al. 2006; Chan et al. 2007) and for studying the mode of action of a”
Application of Mid-infrared and Raman Spectroscopy to the Study of Bacteria (2011, background): “2007), for example: detection of single bacteria within a biofilm, differentiation of bacterial cell wall components from those in the cytoplasm, and monitoring bacterial cellular response due to environmental stress (Xie et al. 2003; Jarvis et al. 2008).”
Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells. (2006, methodology): “In combination with optical trapping (14,15) (also called laser tweezers) where a single laser beam is used for both manipulation and spectral interrogation, Raman spectroscopy of a single, ‘‘trapped’’ cell in suspension over an extended period of time is feasible, provided that the cell is nonadher”