Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men.

By Christina Wang, R. Swerdloff, Ali Iranmanesh, A. Dobs, P. Snyder, G. Cunningham, A. Matsumoto, T. Weber, N. Berman. Journal of Clinical Endocrinology and Metabolism, 2000

912 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Cell Biology, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/e3432f8bb16db4ac4d2bb9487df524bd0a8ef885

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In Cell Biology

1. Tamara B. Harris
2. Vasanti S. Malik

In Endocrinology, Diabetes and Metabolism

1. Simin Liu
2. G. G. Gallup
3. Vasanti S. Malik

Citations in the corpus

• Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. (2006, background): “Testosterone therapy improves the positive and reduces the negative aspects of mood (29).”
• Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. (2010, background): “Testosterone therapy of healthy, hypogonadal men also increases fat-free mass (47, 48, 54– 57) and muscle strength (47, 54) and decreases fat mass (47, 48, 57).”
• Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. (2006, background): “trol through increasing lean body mass in men.(90,105-109) Further, testosterone treatment in men may reduce levels of tumor necrosis factor ,(110,111) an inflammatory cytokine capable of inducing insulin resistance in both adipose and muscle tissues(112-114) and associated with higher risk of type ”
• Sarcopenia: etiology, clinical consequences, intervention, and assessment (2009, background): “The failure of GH treatment to augment muscle strength in elderly subjects has led to other approaches, such as treatment with growth-hormone-releasing hormone, which was found to increase GH production and produce moderate increases in muscle strength [96–100].”
• Handgrip strength predicts sexual behavior, body morphology, and aggression in male college students (2007, background): “It has been repeatedly shown that when testosterone is increased in men with low serum T, HGS increases (Page et al., 2005; Sih et al., 1997; Wang et al., 2000; however, see Malkin et al., 2006, for an exception).”
• The decline of androgen levels in elderly men and its clinical and therapeutic implications. (2005, background): “Whereas several studies that have indicated that androgen treatment improves sexual function of hypogonadal men have included some older patients (369, 420, 443, 445, 488), information from controlled trials specifically on sexual function in the elderly remains scarce.”
• Testosterone dose-response relationships in healthy young men. (2001, positive): “Administration of replacement doses of testosterone to hypogonadal men (10, 12, 30, 45, 49) and of supraphysiological doses to eugonadal men (9, 22–23, 26) increases fat-free mass, muscle size, and strength.”